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intestinal kindlin-1 isoforms can compensate for partial kindlin-1 absence and therefore not all patients have digestive symptoms.6 In Cases 1 and 2, episodes of colitis were reported, associated in Case 2 with encopresis, which led to chronic malnutrition and short stature

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Introduction Alcohol use is a causal risk factor for over 230 disease conditions based on the three-digit International Classification of Diseases, Revision 10 (ICD-10) codes (1)